Substance: Oxymetholone Manufactured by: Axiolabs Packaging: 50 tabs, each tab 50mg Molecular Weight: 332.482 Molecular Formula: C 21 H 32 O 3 Melting Point: 178-180C Effective Dose: 100mgs (optimal) Active Life:Detection Time: up to 8 weeks Androgenic Anabolic Ratio : 45:320
GENERAL INFORMATION:
Oxyplex (Oxymetholone) (commonly called by athletes "A50" or "A-bombs") was initially developed as a compound to help people with anemia, and has since been used very successfully to aid people who are suffering from many other diseases where weight loss is a concern. Thus, it is clearly an effective agent for promoting weight gain, increasing appetite, gaining strength, and increasing Red Blood Cell count. And, as with most Anabolic/Androgenic Steroids (AAS), it has it´s downsides as well. Oxyplex will inhibit your body´s natural production of hormones (testosterone, etc.), will negatively affect your blood lipid profile, can cause water retention, is notorious for causing headaches, and is also highly liver toxic (in fact, it has the worst reputation for hepatoxicity out of all steroids). Paradoxically, although one the benefits touted by it´s original manufacturer is that it can be used to stimulate weight gain through increasing appetite, taking too much may actually inhibit your appetite!
Oxymetholone is without a doubt the strongest and most visibly active steroid to date. Not only does it act very rapidly, it causes a virtual explosion of mass. Gains of up to 10 pounds in 2 weeks are not uncommon. This is largely due to a moderate to low androgenic effect combined with a high anabolic activity also mediated by non-AR mechanisms (mechanisms other than simply binding the androgen receptor).
Water retention is considerable, so that the muscle diameter quickly increases and the user gets a massive appearance within record time. Since the muscle cell draws a lot of water, the entire muscle system of most athletes looks smooth, in part even puffy. Oxyplex does not cause a qualitative muscle gain but rather a quantitative one, which in the off-season is quite welcome. Oxyplex "lubricates" the joints since water is stored there as well. On the one hand this is a factor in the enormous increase of strength and, on the other hand, it allows athletes with joint problems a painless workout.
Power lifters in the higher weight classes are sold on Oxyplex. A strict diet, together with the simultaneous intake of Tamoxiplex (Tamoxifen Citrate) and Proviraplex (Mesterolone), can significantly reduce water retention so that a distinct increase in the solid muscles is possible. By taking Oxyplex the athlete experiences an enormous "pump effect" during the workout in the exercised muscles. The blood volume in the body is significantly elevated causing a higher blood supply to the muscles during workout. Oxyplex increases the number of red blood cells, allowing the muscle to absorb more oxygen. The muscle thus has a higher endurance and performance level. Consequently, the athlete can rely on great power and high strength even after several sets. The highly androgenic effect of Oxyplex stimulates the regeneration of the body so that the often feared "over training" is unlikely. Although Oxyplex is not a steroid used in preparation for a competition, it does help more than any other steroid during dieting to maintain the muscle mass and to allow an intense workout. Many bodybuilders therefore use it up to about one week before a competition, solving the problem of water retention by taking anti-estrogens and diuretics so that they will appear bulky and hard when in the limelight.
HOW DOES IT WORK:
Anabolic steroids work by stimulating the anabolic effect discussed earlier by binding or plugging into protein receptors in or on the cells that help create new proteins in the cells. This increased biological activity is called an increase in Ribonucleic Acid Activity (RNA Activity). The construction of new proteins helps increase muscle size and strength. Remember, this normally happens in the body. The steroids stimulate or increase this biological process by binding to the receptor sites on the protein cells.
Once a drug enters the body, the body begins to process the drug that includes four processes:
1. absorption
2. distribution
3. metabolism
4. excretion
Oxyplex (Oxymetholone) increases the number of red blood cells, allowing the muscle to absorb more oxygen. The muscle thus has a higher endurance and performance level. Consequently, the athlete can rely on great power and high strength even after several sets. Some bodybuilders report such an enormous and in part painful "pump" that they end their workout after only a few sets or work on another muscle. The often-mentioned "steroid pump" manifests itself to an extreme by the intake of Oxyplex and during workout it gives the athlete a fantastic and satisfying sensation. The highly androgenic effect of Oxyplex stimulates the regeneration of the body so that the often-feared "over training" is unlikely. The athlete often feels that only hours after a strenuous workout he is ready for more. Even if he works out six days a week he makes continued progress. Although Oxyplex is not a steroid used in preparation for a competition, it does help more than any other steroid during dieting to maintain the muscle mass and to allow an intense workout. Many bodybuilders therefore use it up to about one week before... competition, solving the problem of water retention by taking anti estrogens and diuretics so that they will appear bulky and hard when in the limelight.
In order to gain a complete understanding of the Oxyplex effects on body, we need to take a look at its advantages contrasted with its disadvantages. Oxyplex is a DHT-derived compound, and is 17-Alpha-Alkylated steroid, meaning that it has been altered at the 17th carbon position to survive oral ingestion. Most oral steroids are 17aa, and this helps them make it through your liver in a useful form. Sounds great, right? Lets 17alpha-alkylate everything! Well& as you can imagine, there´s a down side.
SIDE EFFECTS:
Side effects of steroids depend directly on the dosage.
There are many bodybuilders who take more steroids than they need to see the desired results.
There is no need to take five tablets or injections when one is just as effective.
So, the balance is needed to be kept here.
Since it is 17-alpha alkylated it is very liver-toxic. The compound Oxymetholone easily converts into estrogen. This causes signs of feminization (e.g. gynecomastia) and water retention which in turn requires the intake of anti estrogens (e.g. Tamoxiplex (Tamoxifen Citrate) and Proviraplex (Mesterolone)) and an increased use of diuretics (e.g. Lasix) before a competition. Bodybuilders who experience a severe steroid acne caused by Oxyplex can get this problem under control by using the prescription drug Roaccutan.
Possible side effects may include headaches, nausea, vomiting, stomach aches, lack of appetite, insomnia, and diarrhea.
STACKING AND USAGE:
As such it has a good degree of hepatoxicity and should not be used for longer than 6 weeks on end and it is highly recommended that you get your liver values checked regularly. Because of its long activity and poor affinity (due the the 17AA) good results can be obtained with a single daily dose, so spreading your doses out is an option but is anything but necessary. A single dose of 50-100 mg every day is recommended, but doses as high as 150 or 200 are used by experienced bodybuilders as well. Due to its rapid action and high toxicity, its mostly used to kickstart a longer injectable cycle in the first 3-5 weeks of that cycle. It will add a lot of mass and strength on immediately, getting you through the low-result beginning of an injectable cycle. Its use is thus very similar to that of Methanoplex (Methandienone), but with the latter being slightly more versatile.
What is an Oxyplex Cycle? How much should you use? Well, this is actually one of the most interesting facts about Oxyplex. You see, most steroids produce what we call a "dose respondent curve" which is a fancy way of saying "the more you use, the more you gain."
Oxyplex is one of the few steroids where the dose respondent curve flattens out very quickly. When you take 50mgs of Oxyplex, you´ll make some very good gains. When you take 100mgs of Oxyplex, you´ll make even more gains. However, it has been found that 100mgs/day is as effective for weight gain as 150mgs/day but produces less side effects and was less toxic (4). I feel that the jump from 50mgs to 100mgs constitutes an acceptable rise in benefit vs. cost, but this is not the case as dosages get over 100mgs. Now, lets see how 50mgs and 100mgs of Oxymetholone actually effect strength, when compared with each other:
Relative (%) changes in strength are shown for the groups receiving placebo (filled bars), 50 mg/day Oxymetholone (open bars), and 100 mg/day Oxymetholone (gray bars). Nos. above bars represent relative change (%) from baseline to week 12 for the 1-repetition maximum tests of strength. Error bars represent ± 1 SE from the mean. * Significant difference from placebo, P
As you can see, in this study, doubling the dose of Oxyplex nearly doubled the strength gains of the test subjects. Now, when we look at changes in body composition from Oxymetholone we can see that although the guys taking the 100mgs (vs. the 50mgs group) had more fat lost and more Lean Body Mass gained, it wasn´t as dramatic as the differences in strength gains between the two groups:
Changes in body composition are shown for the groups receiving placebo (filled bars), 50 mg of Oxymetholone per day (open bars), and 100 mg per day (gray bars). Numbers above the bars represent the mean absolute changes and the error bars are ± 1 SE. For total lean body mass (LBM) and total fat, differences among the 3 groups were significant (P
After discontinuing Oxyplex, it is important to continue steroid treatment with another compound since, otherwise, a drastic reduction takes place and the user, as is often observed, within a short period looks the same as before the treatment. No other anabolic/androgenic steroid causes such a fast and drastic loss in strength and mass as does Oxyplex . Athletes should continue their treatment with injectable testosterone such as Sustaplex 325 (Sustanon) or Testaplex E 250 (Testosterone Enanthate) for several weeks. Bodybuilders often combine Oxyplex with Decaplex 275 (Nandrolone Decanoate) or Testosterone to build up strength and mass. A very effective stack which is also favored by professionals consists of Oxyplex 100 mg+/day, Trenaplex A 100 (Trenbolone Acetate) 228 mg+/week, and Sustaplex 325 500 mg+/week. This stack quickly improves strength and mass but it is not suitable for and steroid novices. Oxyplex is not a steroid for novices and should only be used after the athlete has achieved a certain development or has had experience with various "weaker" compounds. Stories that the elite bodybuilder uses 8-10 or more Oxyplex tablets daily belongs to the realm of fairy tales. It is rare that any ambitous competing bodybuilder can do without the support of 50 mg Oxymetholone tablets; however, taking 8, 10 or 12 tablets daily is more than the organism can handle. Oxyplex is to be taken seriously and the prevailing bodybuilder mentality "more is better" is out of place.
As an interesting side note, some of the medical literature on this compound suggests a dose of 1-5mgs per kg of bodyweight. I´ll pause a second here for you to figure out how absurdly high of a dose that would translate to for the average bodybuilder! It is worth mentioning that PCT should be taken into consideration for every cycle.
USEFUL INFO:
Women and Oxyplex
Oxyplex (Oxymetholone) is not recommended for women since it causes many and, in part, irreversible virilizing symptoms such as acne, clitorial hypertrophy, deep voice, increased hair growth on the legs, beard growth, missed periods, increased -libido, and hair loss. Oxyplex is simply too strong for the female organism and accordingly, it is poorly tolerated. Some national and international competing female athletes, however, do take Oxyplex during their "mass building phase" and achieve enormous progress. Women who do not want to give up the distinct performance-enhancing effect of Oxyplex but, at the same time, would like to reduce possible side effects caused by androgen, could consider taking half a tablet (25mg) every two days, combined with a "mild" injectable anabolic steroid such as Primoplex 100 (Methenolone Enanthate) or Decaplex 275 (Nandrolone Decanoate). Ultimately, the use of Oxyplex and its dosage are an expression of the female athlete's personal willingness to take risks. In schools of medicine Oxyplex is used in the treatment of bone marrow disorders and anemia with abnormal blood formation.