Letroplex (Letrozole tablets) for oral administration contain 2.5 mg of Letroplex, a nonsteroidal aromatase inhibitor (inhibitor of estrogen synthesis).
Letroplex is a white to yellowish crystalline powder, practically odorless, freely soluble in dichloromethane, slightly soluble in ethanol, and practically insoluble in water.
Letroplex (Letrozole) is the third generation Aromatase Inhibitor (AI). This drug was developed to fight breast cancer by inhibiting the aromatization. It is usually used as a part of an aggressive treatment in post-menopausal women, to fight and reverse the spread of breast cancer after other treatments (such as Tamoxiplex (Tamoxifen Citrate) therapy) has failed. It´s probably the most efficient product on the market for this purpose currently It is very similar in structure and action to it´s predecessor Arimiplex (Anastrozole).
Letroplex is highly specific in inhibiting aromatase activity. There is no impairment of adrenal steroidogenesis. No clinically-relevant changes were found in the plasma concentrations of cortisol, aldosterone, 11-deoxycortisol, 17-hydroxy-progesterone, ACTH or in plasma renin activity among post-menopausal patients treated with a daily dose of Letroplex 0.1 mg to 5 mg.
In the world of bodybuilding it is used to reduce or eliminate excess estrogen caused by the use of aromatizing steroids.
Letroplex is currently the strongest aromatase inhibitor available. In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more . However, it's use and benefits are not limited to eliminating estrogen in women.
In one male test subject Letroplex was able to reduce estrogen levels to undetectable levels , and in another clinical study done on both young and elderly men, intravenous administration of Letroplex lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects.
Letroplex was studied in men, and found to significantly increase LH levels to a 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. Letroplex was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively . In a similar study 0.02 mg of Letroplex increased testosterone by 45% after 2 days. That same twenty micrograms of Letroplex was also enough, in one study done on men, to reduce estrogen levels by roughly a third.
Letroplex has a 2-4 day half-life, and it needs to be taken for up to 60 days to get a steady blood plasma level .
Letroplex also does quite a few things which would be of interest to both bodybuilders and athletes. Firstly, it has been shown to reduce estrogen levels by 98% or greater. In at least one documented incidence, Letroplex reduced estrogen in the test subject to undetectable levels, and increased LH, FSH and SHBG (4). Clearly this is all of interest to bodybuilders, as less estrogen in the body means less chance of certain side effects such as water-retention, Gynocomastia, and acne. This makes Letroplex an appropriate choice for even the heaviest bulking or cutting cycles including harsh androgens. Also, if you are a competitive bodybuilder, Letroplex is a must have product for contest prep; no other Ancillary compound will produce a dry and tight look like Letro will.
HOW DOES IT WORK:
Letroplex is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumorbearing female animals, Letroplex is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. Letroplex selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis.
As previously mentioned, Letroplex can be used to raise LH and FSH (which are hormones which signal your testes to produce more testosterone). It also, of course, will raise your testosterone levels via this mechanism. Again, this is of interest to athletes and bodybuilders for obvious reasons. Letroplex, of course, can be used for post-cycle-therapy (PCT) to raise test levels, but for various reasons, Tamoxiplex may be a better choice. Still, I have successfully used Letroplex for this purpose.
How good is this compared with Aromasin and Arimiplex, it´s too other main rivals? Well, In non-cellular systems, Letroplex is 2-5 times more potent than anastrozole and exemestane in its inhibition of the aromatase enzyme and activity, and in cellular systems it is 10-20x more potent! It also lasts quite a long time in your body,but takes awhile to get going& Letroplex has a whopping 2-4 day (!) ½ life, and you need to take Letroplex for 60 days to get a steady blood plasma level.
Letroplex´s effects on serum lipids (cholesterol, both HDL and LDL) are, in the words of one researcher: "inconsistent. " Clearly, however, you´ll eventually suffer an impaired lipid profile and immune system if you keep your estrogen levels too low for too long. Your sex drive will also probably suffer from extraordinarily low levels of estrogen present.
SIDE EFFECTS:
This drug is generally well tolerated. Fatigue, nausea, constipation , diarrhea , headache , drowsiness or dizziness may occur. If these persist or worsen, notify your doctor promptly. Unlikely but report promptly: chest pain, stomach pain, trouble breathing, hot flushes, rash , itching. Very unlikely but report promptly: swelling/redness/weakness/ pain in legs or arms, vision problems. If you notice other effects not listed above, contact your doctor or pharmacist.
STACKING AND USAGE:
An effective dose of Letroplex is .25-.5mg/day, but be forewarned, if you go over that amount, it can kill your sex drive. Also worth noting is that there´s a rebound effect on your estrogen when you come off Letroplex. Maximum inhibition of the aromatase enzyme has been found to happen at doses as low as 100mcg!