Substance: Exemestane Manufactured by: Axiolabs Packaging: 25 tabs, 25mg/tab Water Retention: none Aromatization: no DHT Conversion: no Half life: 27 hours
GENERAL INFORMATION:
Exeplex (Exemestane) is a steroidal suicide aromatase inhibitor, which means that it lowers estrogen production in the body by blocking the aromatase enzyme, the enzyme responsible for estrogen synthesization.
Exemestane is one of those weird compounds that nobody really knows what to do with. What we generally hear about it makes it very uninteresting… It's a third generation Aromatase Inhibitor (AI) just like Arimiplex (Anastrozole) and Letroplex (Letrozole). Both of those two drugs are very efficient at stopping the conversion of androgens into estrogen, and since we have them, why bother with Exeplex?
Exeplex was developed to fight breast cancer in post-menopausal women, who need a particularly aggressive therapy, and for whom first line defenses such as SERMS (Tamoxifen) have not worked. This should be our first clue in inferring that this stuff is pretty strong, or at least stronger than some of the other compounds which are used to fight breast cancer.
Exemestane may be useful on an extreme cutting cycle, leading up to a bodybuilding contest, or if you are particularly prone to gyno.
Since Exeplex is about 65% efficient at suppressing estrogen , it's certainly a very powerful agent, especially considering you won't experience reduced effectiveness because of your concurrent use of Tamoxiplex (Nolvadex) or from any sort of tolerance developed by using other Aromatase Inhibitors on your cycle. There is also a decent amount of preclinical data suggesting that Exeplex has a beneficial effect on bone mineral metabolism that is not seen with non-steroidal agents, and it may also have beneficial effects on lipid metabolism that are not found in the non-steroidal Letroplex and Arimiplex.
HOW DOES IT WORK:
Exeplex averages an 85% rate of estrogen suppression , so it´s clearly a very effective agent for bodybuilders and other athletes wanting to avoid estrogen related side effects such as gyno, acne, or water-retention brought on by aromatizing steroids. Specifically, Exeplex dose this by selectively inhibiting aromatase activity in a time-dependent and irreversible manner (hence the "suicidal" portion of it´s name).
Despite its steroidal structure, Exemestane does not have hormonal or anti-hormonal activity, except for a slight androgenic activity. In the early and late phase II clinical trials conducted in Japan on postmenopausal breast cancer patients who received 25 mg/day of Exemestane, the response rates were 31.4% and 24.2%, respectively. Blood estrogen levels were also markedly reduced. These results confirmed the clinical relevance of non-clinical study results.
The active ingredient is a white to slightly yellow crystalline powder with a molecular weight of 296.41. Exemestane is freely soluble in N, N-dimethylformamide, soluble in methanol, and practically insoluble in water.
Each Exeplex Tablet contains the following inactive ingredients: mannitol, crospovidone, polysorbate 80, hydroxypropyl methylcellulose, colloidal silicon dioxide, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, simethicone, polyethylene glycol 6000, sucrose, magnesium carbonate, titanium dioxide, methylparaben, and polyvinyl alcohol.
The estrogen suppression rate for Exemestane varies from 85% to 95%.
As with most of the compounds in this class, it also causes a reasonable rise in testosterone levels , and as you may have guessed, this rise in testosterone means that Exemestane can also cause androgenic sides. As you can see from the chart below, Exemestane is very effective at both lowering estrogen (estradiol) and raising testosterone.
SIDE EFFECTS:
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. This medicine might make you feel sleepy, dizzy or weak and could therefore affect your mental or physical ability to safely drive or operate machinary. You should be aware of how you react to this medicine before driving or operating machinary.
STACKING AND USAGE:
25mgs is a very effective dosage. As an added benefit, Exemestane not only increases testosterone and lowers estrogen, but it also increases IGF levels. Additionally Worth noting is that Exeplex may possibly be less harsh on blood lipids than some of the other (similar) compounds we use in the world of bodybuilding or athletics (other Aromatase Inhibitors). It also has, at best no effect on IGF, and at worst could lower (13) it. Aromatase Inhibitors are very tricky with regards to inconsistencies in IGF levels.
The ability of Exemestane to lower estrogen levels by the aforementioned 85% makes it a very nice choice for use in any cycle where aromatizing steroids are used. In addition, since it´s not too harsh at all on blood lipid profiles, it´s a very good choice for longer cycles. It´s ability to raise both testosterone levels also seem to suggest that it would be a very nice addition to a Post-Cycle-Therapy
Unfortunately, you need to take Exemestane for a week to reach steady blood plasma levels of it, and Exemestane has a half life of 27 hours.