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Substance: Clomiphene Citrate
Manufactured by: Axiolabs
Packaging: 1 x 20 tabs (50mg) 

Active Life: 5-7 days
Average Dose : Men 50-100 mg/day
Acne: Yes
Water Retention: No
High Blood Pressure : Rare
Liver Toxic: Low
Aromatization: None
Decrease HPTA function : No, used to restore it

GENERAL INFORMATION :

Clomiplex is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle, improving testosterone production of endurance athletes, and is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids.
Clomiplex is the commonly referenced brand name for the drug clomiphene citrate. It is not an anabolic steroid, but a prescription drug generally prescribed to women as a fertility aid. This is due to the fact that clomiphene citrate shows a pronounced ability to stimulate ovulation. This is accomplished by blocking/minimizing the effects of estrogen in the body. To be more specific Clomiplex is chemically a synthetic estrogen with both agonist/antagonist properties, and is very similar in structure and action to Tamoxiplex (Nolvadex).

HOW DOES IT WORK:

Clomiplex is a medication that promotes the production of the body's own stimulating hormone, gonadotropin, which in turn increases the production of hormone testosterone. It is, for example, administered to women as a so-called antiestrogen to trigger ovulation ("ovulation stimulator").
Although Clomiplex is a synthetic estrogen it also works as an anti-estrogen. The reason is that Clomiplex has only a very low estrogenic effect and thus the stronger estrogens which, for example, are generated during the aromatization of steroids, are blocked at the receptors. These would include those that develop during the aromatizing of steroids. This does not prevent the steroids from aromatizing but the increased estrogen is mostly deactivated since it cannot attach to the receptors. The increased water retention and the possible signs of feminization can be reduced or even completely avoided. Since the antiestrogenic effect of Clomiplex is lower than those found in Proviraplex (Proviron), Tamoxiplex (Nolvadex), and Teslac it is especially taken as a testosterone stimulant.
Clomiplex is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites.  Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/ Clomiplex complex, but others are blocked due to the change in shape.  The result is that in some tissues Clomiplex acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomiplex acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Clomiplex is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.
The drug seems to have estrogenic effects on mood, which can be beneficial (improving relationships with women by improving empathy) or can yield depression or PMS-like symptoms, but for most users there is no significant effect either way.
Clomiplex also has the property of reducing the adverse effect of exercise-induced damage of muscle tissue. This is very significant for endurance athletes but is not very significant, if at all significant, with reasonable weight training. Clomiplex does not perceptibly affect gains of the weight trainer either favorably or adversely in my experience.

SIDE EFFECTS:

Generally well tolerated.
Patients on prolonged clomiphene citrate therapy may show elevated serum levels of desmosterol.
Possible side effects are climacteric hot flashes and occasional visual disturbances which can manifest themselves in blurred vision, giving flickering or flashing. Should visual disturbances occur, the manufacturer recommends discontinuing Clomiplex treatment.

STACKING AND USAGE:

The claim that duration of intake should not exceed 10-14 days is incorrect. Clinical studies with male patients have been for periods of a year or longer. This error probably originates from the fact that, for use in women, due to the menstrual cycle there would obviously be no point in trying to stimulate ovulation all four weeks of the month. Thus, use in women is limited to 10-14 days. That limitation is not because of toxicity.
The dosage, 50-100 mg/day (1 -2 tablets) seems to be sufficient. The tablets are usually taken with fluids after meals. If several tablets are taken it is recommended that they be administered in equal doses distributed through-out the day.
Most athletes begin with 100 mg/day, taking one 50 mg tablet every morning and evening after meals. After the fifth day the dosage is often reduced to only one 50 mg tablet per day It is normally not necessary to take the drug for more than ten days in order to increase the endogenous testosterone production.

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