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GP Exemestane
33.00 USD GP Exemestane
General information:
Manufacturer: Geneza Pharmaceuticals
Substance: Exemestane
Pack: 20 tabs (25 mg/tab)
Exemestane is an oral steroidal aromatase inhibitor (but also known uniquely as an aromatase inactivator) used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. An aim in the treatment of hormone-receptor-positive patients in preventing recurrence is to lower estrogen levels that this breast cancer thrives on.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced in the adrenal gland from the conversion of androgens into estrogen by the aromatase enzyme. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." In other words, Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogens.
The estrogen suppression rate for exemestane varies from 85% for estradiol (E2) to 95% for estrone (E1).
Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy.
Exemestane is indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
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Forget gym, steroids and other hulk protein can help muscles grow
MELBOURNE: If you hate the idea of hitting the gym, a new 'hulk' protein can help you achieve a toned and muscular look, scientists claim. Scientists in Australia say they have discovered one of the molecular keys to a protein that promotes weight and muscle mass gain, without any exercise involved like steroids. Researchers found that by blocking the function of Grb10, nicknamed the 'Hulk' protein , while mice were in the womb, they were considerably stronger and more muscular at birth than normal mice.
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Effects of Anabolic Steroids
This article is mainly supposed for beginners in steroids usage, for those who want to begin a steroids cycle and still doubt about the expected effects of anabolic steroids, it will be useless for old juicers or steroids experts. I want to mention that this is not a promotional article, so please don't treat me wrongly, If you doubt about beginning steroids usage then please don't think we are trying to convince you to begin juicing, this article has been written for informational purpose only.
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Human Growth Hormone
This article has been written to list the main points to consider for the guys who want to begin using Human Growth Hormone. This is not a scientific article and I am not an expert in endocrinology, so I won't blow up your mind with smart-looking phrases and medical terminology, I won't speak about Human Growth Hormone and society, human growth hormone and diabetes, chromosomes, polypeptides bla bla bla, you can find all these in any medical encyclopedia. I've just put together the answers to the most important questions which can appear while beginning usage of human growth hormone. Somebody will consider this article stupid but I hope there will be some people who will find it useful.